There are a lot of beautiful islands and island communities around there, just follow the scent of $$$$$. Certainly you know that from LaLa land. All kidding aside if you are flying into Tampa the Dali museum is a must see. If you are into steaks, the best steak house in the US, I've been to a lot of them, is Berns (
http://www.bernssteakhouse.com/). Simply the best, it certainly puts to shame the chains (Morton's, Ruth Chris's, Sullivans), as well as other noted Steak houses such a s Peter Lugers. This does require reservations well in advance though and is not cheap.
There are a few water Gardens nearby, but I'm having a senior moment and can't remember them. However, the best way to see the area is by vehicle (bike or car) and being flexible to explore. The heat and humidity is also not as oppressive as south Florida so it should be reasonable.
have a god time.